Engineering the Next Generation of Biomaterials for Regenerative Medicine, Drug Delivery and Disease Modeling

Engineering the Next Generation of Biomaterials for Regenerative Medicine, Drug Delivery and Disease Modeling

Gaharwar Lab - Where Science Shapes Innovation

For full list of publications go to Google Scholar (Link)

Total publications: 155

2025

Designing the Next Generation of Biomaterials through Nanoengineering

  • R Davis, I Duggal, N A Peppas, A K Gaharwar
  • Advanced Materials
  • 2501761

Nanosilicates promote angiogenesis through activation of ROS-mediated WNT/β-catenin pathway

  • G. Lokhande, K. A. Singh, S. Roy, J. Soukar, A. Kersey, P. Borkar, S. Biswas, R. U. R. Syed, A. Keller, K. J. Bayless, I. Singh, and A. K. Gaharwar
  • Science Advances
  • 11
  • 27

Repairing and preserving the cellular powerplant with nanotechnology

  • J Soukar, K A Singh, A K Gaharwar
  • Nanomedicine
  • 1-3

Nanoengineered Hydrogels and Uses Thereof

  • K Deo, A K Gaharwar
  • US Patent App.
  • 18/943,159

Protein structure and bioactivity upon adsorption and desorption from nanosilicate sustained release delivery devices

  • S Stealey, E Dharmesh, A K Gaharwar, J S Rudra, S P Zustiak
  • Nanoscale
  • 17
  • 13477-13488

High‐Speed Embedded Ink Writing of Anatomic‐Size Organ Constructs

  • W. Hua, C. Zhang, H. Cui, K. Mitchell, D.K. Hensley, J. Chen, C. Do, L. Raymond, R. Coulter, E. Bandala, F. Rubbi, G. Chai, Z. Zhang, Y. Liao, D. Zhao, Y. Wang, A.K. Gaharwar, Y. Jin
  • Advanced Science
  • 12 (13)
  • 2405980

Organelle‐Targeting Nanoparticles

  • Soukar J, Peppas NA, Gaharwar AK*
  • Advanced Science
  • 12 (7)
  • 2411720

Nanoengineered Shape‐Memory Hemostat

  • Sarah E Hargett, Giriraj K Lokhande, Joseph Duran, Zanir Hirani, Lindy K Jang, Samantha Foster, Kaivalya A Deo, Sasha George, Mahjabeen Javed, Taylor H Ware, Duncan J Maitland, Akhilesh K Gaharwar
  • Small Science
  • 5 (2)
  • 2400321

2024

Matrix stiffness drives drop like nuclear deformation and lamin A/C tension-dependent YAP nuclear localization

  • Ting-Ching Wang, Samere Abolghasemzade, Brendan P McKee, Ishita Singh, Kavya Pendyala, Mohammad Mohajeri, Hailee Patel, Aakansha Shaji, Anna L Kersey, Kajol Harsh, Simran Kaur, Christina R Dollahon, Sasanka Chukkapalli, Pushkar P Lele, Daniel E Conway, Akhilesh K Gaharwar, Richard B Dickinson, Tanmay P Lele
  • Nature Communications
  • 15 (1)
  • 10151

Atomic vacancies of molybdenum disulfide nanoparticles stimulate mitochondrial biogenesis

  • Kanwar Abhay Singh, John Soukar, Mohammad Zulkifli, Anna Kersey, Giriraj Lokhande, Sagnika Ghosh, Aparna Murali, Natalie M Garza, Harman Kaur, Justin N Keeney, Ramu Banavath, Hatice Ceylan Koydemir, Raquel Sitcheran, Irtisha Singh, Vishal M Gohil, Akhilesh K Gaharwar
  • Nature Communications
  • 15 (1)
  • 8136

Global trends in clinical trials involving engineered biomaterials

  • Mahima Lele, Shaunak Kapur, Sarah Hargett, Nivedhitha Malli Sureshbabu, Akhilesh K Gaharwar
  • Science Advances
  • 10 (29)
  • eabq0997

High-Throughput 3D-Printed Model of the Feto-Maternal Interface for the Discovery and Development of Preterm Birth Therapies

  • Rahul Cherukuri, Ananth Kumar Kammala, Tilu Jain Thomas, Leah Saylor, Lauren Richardson, Sungjin Kim, Marc Ferrer, Cristina Acedo, Min Jae Song, Akhilesh K Gaharwar, Ramkumar Menon, Arum Han
  • ACS Applied Materials & Interfaces
  • 16 (32)
  • 41892–41906

Enhanced wound healing by nanoengineered hydrogel patch loaded with connective tissue growth factor

  • Syed Raza ur Rehman, Asad Ullah, Robin Augustine, Yogesh B Dalvi, Alap Ali Zahid, Nureddin Ashammakhi, Akhilesh K Gaharwar, Khalid Al-Saad, Rashad Alfkey, Anwarul Hasan
  • Materials Today Communications
  • 40
  • 109825

Granular Biphasic Colloidal Hydrogels for 3D Bioprinting

  • Kaivalya A Deo, Aparna Murali, James J Tronolone, Cole Mandrona, Hung Pang Lee, Satyam Rajput, Sarah Hargett, Amirali Selahi, Yuxiang Sun, Daniel Alge, Abhishek Jain, Akhilesh K Gaharwar
  • Advanced Healthcare Materials
  • 13 (25)
  • 2303810

Inorganic Biomaterials Shape the Transcriptome Profile to Induce Endochondral Differentiation

  • Aparna Murali, Anna M Brokesh, Lauren M Cross, Anna L Kersey, Manish K Jaiswal, Irtisha Singh, Akhilesh Gaharwar
  • Advanced Science
  • 11 (29)
  • 2402468

GHSR Deletion in β-Cells of Male Mice: Ineffective in Obesity, but Effective in Protecting against Streptozotocin-Induced β-Cell Injury in Aging

  • Hye Won Han, Geetali Pradhan, Daniel Villarreal, Da Mi Kim, Abhishek Jain, Akhilesh Gaharwar, Yanan Tian, Shaodong Guo, Yuxiang Sun
  • Nutrients
  • 16 (10)
  • 1464

Inorganic Ions Activate Lineage-Specific Gene Regulatory Networks

  • Anna L Kersey, Irtisha Singh, Akhilesh K Gaharwar
  • Acta Biomaterialia
  • 183
  • 371-386

Animal models of postpartum hemorrhage

  • Sarah E Hargett, Elaine F Leslie, Hector O Chapa, Akhilesh K Gaharwar
  • Lab Animal
  • 53 (4)
  • 93–106

2023

A synthetic tumour microenvironment

  • Akhilesh K Gaharwar, Irtisha Singh
  • Nature Materials
  • 22
  • 412-413

Omics-based approaches to guide the design of biomaterials

  • Anna L Kersey, Thuy-Uyen Nguyen, Biswadeep Nayak, Irtisha Singh, Akhilesh K Gaharwar
  • Materials Today
  • 64
  • 98-120

Dynamically Cross-Linked Granular Hydrogels for 3D Printing and Therapeutic Delivery

  • Hung-Pang Lee, Ryan Davis Jr, Ting-Ching Wang, Kaivalya A Deo, Kathy Xiao Cai, Daniel L Alge, Tanmay P Lele, Akhilesh K Gaharwar
  • ACS Applied Bio Materials
  • 6 (9)
  • 3683–3695

Nanobio Interface Between Proteins and 2D Nanomaterials

  • Shounak Roy, Aastha, Kaivalya A Deo, Kashmira Dey, Akhilesh K Gaharwar, Amit Jaiswal
  • ACS Applied Materials & Interfaces
  • 15 (30)
  • 35753–35787

Laponite-Based Nanocomposite Hydrogels for Drug Delivery Applications

  • Samuel T Stealey, Akhilesh K Gaharwar, Silviya Petrova Zustiak
  • Pharmaceuticals
  • 16 (6)
  • 821

Dynamically crosslinked thermoresponsive granular hydrogels.

  • Hung-Pang Lee, Kathy Xiao Cai, Ting-Ching Wang, Ryan Davis Jr, Kaivalya Deo, Kanwar Abhay Singh, Tanmay P Lele, Akhilesh K Gaharwar
  • Journal of Biomedical Materials Research. Part A
  • 111 (10)
  • 1577-1587

Multi-leveled Nanosilicate Implants Can Facilitate Near-Perfect Bone Healing

  • Mozhgan Keshavarz, Parvin Alizadeh, Firoz Babu Kadumudi, Gorka Orive, Akhilesh K Gaharwar, Miguel Castilho, Nasim Golafshan, Alireza Dolatshahi-Pirouz
  • ACS Applied Materials & Interfaces
  • 15 (17)
  • 21476–21495

2022

Nanoengineered Ink for Designing 3D Printable Flexible Bioelectronics

  • Kaivalya A Deo, Manish K Jaiswal, Sara Abasi, Giriraj Lokhande, Sukanya Bhunia, Thuy-Uyen Nguyen, Myeong Namkoong, Kamran Darvesh, Anthony Guiseppi-Elie, Limei Tian, Akhilesh K Gaharwar
  • ACS nano
  • 16 (6)
  • 8798–8811

Dissociation of nanosilicates induces downstream endochondral differentiation gene expression program

  • Anna M Brokesh, Lauren M Cross, Anna L Kersey, Aparna Murali, Christopher Richter, Carl A Gregory, Irtisha Singh, Akhilesh K Gaharwar
  • Science advances
  • 8 (17)
  • eabl9404

Nano-bio Interactions of 2D Molybdenum disulfide

  • S Roy, K Deo, KA Singh, HP Lee, A Jaiswal, AK Gaharwar
  • Advanced Drug Delivery Reviews
  • 187
  • 114361

2D Covalent Organic Framework Direct Osteogenic Differentiation of Stem Cells

  • S Bhunia, MK Jaiswal, KA Singh, KA Deo, AK Gaharwar
  • Advanced Healthcare Materials
  • 11 (10)
  • 2101737

2D Nanosilicate for additive manufacturing: Rheological modifier, sacrificial ink and support bath

  • Satyam Rajput, Kaivalya A Deo, Tanmay Mathur, Giriraj Lokhande, Kanwar Abhay Singh, Yuxiang Sun, Daniel L Alge, Abhishek Jain, Tapasree Roy Sarkar, Akhilesh K Gaharwar
  • Bioprinting
  • 25
  • e00187

Designing Cost-Effective Open-Source Multihead 3D Bioprinters

  • D Chimene, KA Deo, J Thomas, L Dahle, C Mandrona, AK Gaharwar
  • GEN Biotechnology
  • 1 (4)
  • 386-400

Silicone-containing thermoresponsive membranes to form an optical glucose biosensor

  • Ping Dong, Kanwar Abhay Singh, Amelia M Soltes, Brian S Ko, Akhilesh K Gaharwar, Michael J McShane, Melissa A Grunlan
  • Journal of Materials Chemistry B
  • 32 (10)
  • 6118-6132

Injectable, Self‐healing, and 3D Printable Dynamic Hydrogels

  • HP Lee, KA Deo, J Jeong, M Namkoong, KY Kuan, L Tian, AK Gaharwar
  • Advanced Materials Interfaces
  • 9 (23)
  • 2201186

Electrically Conductive MoS2 Reinforced Polyacrylonitrile Nanofibers for Biomedical Applications

  • Bhuvaneshwari Balasubramaniam, Shreedevi Arun Kumar, Kanwar Abhay Singh, Sukanya Bhunia, Kartikey Verma, Limei Tian, Raju Kumar Gupta, Akhilesh K Gaharwar
  • Advanced NanoBiomed Research
  • 2 (4)
  • 2100105

Coiled Coil Crosslinked Alginate Hydrogels Dampen Macrophage-Driven Inflammation

  • Zain Clapacs, Conor L ONeill, Paresh Shrimali, Giriraj Lokhande, Megan Files, Darren D Kim, Akhilesh K Gaharwar, Jai S Rudra
  • Biomacromolecules
  • 23 (3)
  • 1183-1194

2021

Light‐Triggered In Situ Gelation of Hydrogels using 2D Molybdenum Disulfide (MoS2) Nanoassemblies as Crosslink Epicenter

  • HP Lee, G Lokhande, KA Singh, MK Jaiswal, S Rajput, AK Gaharwar
  • Advanced Materials
  • 33 (23)
  • 2101238

Emerging 2D nanomaterials for biomedical applications

  • A Murali, G Lokhande, KA Deo, A Brokesh, AK Gaharwar
  • Materials Today
  • 50
  • 276-302

4D Printing of Engineered Living Materials

  • Laura K Rivera‐Tarazona, Tarjani Shukla, Kanwar Abhay Singh, Akhilesh K Gaharwar, Zachary T Campbell, Taylor H Ware
  • Advanced Functional Materials
  • 32 (4)
  • 2106843

Generalizing hydrogel microparticles into a new class of bioinks for extrusion bioprinting

  • Shangjing Xin, Kaivalya A Deo, Jing Dai, Navaneeth Krishna Rajeeva Pandian, David Chimene, Robert M Moebius, Abhishek Jain, Arum Han, Akhilesh K Gaharwar, Daniel L Alge
  • Science advances
  • 7 (42)
  • eabk3087

Two‐dimensional Metal Organic Frameworks for Biomedical Applications

  • Shreedevi Arun Kumar, Bhuvaneshwari Balasubramaniam, Sukanya Bhunia, Manish K Jaiswal, Kartikey Verma, Ali Khademhosseini, Raju Kumar Gupta, Akhilesh K Gaharwar
  • WIREs Nanomedicine and Nanobiotechnology
  • 13 (2)
  • e1674

3D Bioprinted Multicellular Vascular Models

  • Karli A Gold, Biswajit Saha, Navaneeth Krishna Rajeeva Pandian, Brandon K Walther, Jorge A Palma, Javier Jo, John P Cooke, Abhishek Jain, Akhilesh K Gaharwar
  • Advanced Healthcare Materials
  • 10 (21)
  • 2101141

Mineral-based nanoparticles for arthritis treatment

  • AK Gaharwar, JK Carrow
  • United States. Patent and Trademark Office

Self‐Oscillating 3D Printed Hydrogel Shapes

  • Ilse B Nava‐Medina, Karli A Gold, Savannah M Cooper, Kyle Robinson, Abhishek Jain, Zhengdong Cheng, Akhilesh K Gaharwar
  • Advanced Materials Technologies
  • 6 (12)
  • 2100418

Human tumor microenvironment chip evaluates the consequences of platelet extravasation and combinatorial antitumor-antiplatelet therapy in ovarian cancer

  • Biswajit Saha, Tanmay Mathur, James J Tronolone, Mithil Chokshi, Giriraj K Lokhande, Amirali Selahi, Akhilesh K Gaharwar, Vahid Afshar-Kharghan, Anil K Sood, Gang Bao, Abhishek Jain
  • Science Advances
  • 7 (30)
  • eabg5283

2D Layered Nanomaterials for Therapeutics Delivery

  • R Davis Jr, RA Urbanowski Jr, AK Gaharwar
  • Current Opinion in Biomedical Engineering
  • 20
  • 100319

2020

Photothermal modulation of human stem cells using light-responsive 2D nanomaterials

  • JK Carrow*, KA Singh*, MK Jaiswal, A Ramirez, G Lokhande, AT Yeh, ...
  • Proceedings of the National Academy of Sciences
  • 117 (24)
  • 13329-13338

Biomedical applications of additive manufacturing

  • P Dhavalikar, Z Lan, R Kar, K Salhadar, AK Gaharwar, ...
  • Biomaterials Science
  • 623-639

Light‐Responsive Inorganic Biomaterials for Biomedical Applications

  • HP Lee, AK Gaharwar
  • Advanced Science
  • 7 (17)
  • 2000863

Engineered biomaterials for in situ tissue regeneration

  • AK Gaharwar, I Singh, A Khademhosseini
  • Nature Reviews Materials
  • 5
  • 686–705

Nanoengineered Light‐Activatable Polybubbles for On‐Demand Therapeutic Delivery

  • S Arun Kumar, J Good, D Hendrix, E Yoo, D Kim, KA Deo, YY Jhan, ...
  • Advanced Functional Materials
  • 30 (31)
  • 2003579

2D Covalent Organic Frameworks for Biomedical Applications

  • S Bhunia, KA Deo, AK Gaharwar
  • Advanced Functional Materials
  • 30 (27)
  • 2002046

Self-Assembly of Block Heterochiral Peptides into Helical Tapes

  • TM Clover, CL ONeill, R Appavu, G Lokhande, AK Gaharwar, AE Posey, ...
  • Journal of the American Chemical Society
  • 142 (47)
  • 19809–19813

Nanocomposite Ionic-Covalent Entanglement Reinforcement Mechanism and Hydrogel

  • AK Gaharwar, D Chimene
  • US Patent
  • WO/2018/169,965

Conditioning of 3D Printed Nanoengineered Ionic–Covalent Entanglement Scaffolds with iP‐hMSCs Derived Matrix

  • C Sears, E Mondragon, ZI Richards, N Sears, D Chimene, EP McNeill, ...
  • Advanced Healthcare Materials
  • 9 (15)
  • 1901580

Nanoengineered Osteoinductive Bioink for 3D Bioprinting Bone Tissue

  • D Chimene, L Miller, L Cross, MK Jaiswal, I Singh, AK Gaharwar
  • ACS Applied Materials & Interfaces
  • 12 (14)
  • 15976-15988